Cell-Derived Xenografts

Cell lines derived from human tumoral primary cells are widely used in scientific research. We have almost 200 cell lines models most of which have been tested for their capacity to grow as subcutaneous xenografts in immunodeficient mice.

Our approval for animal experimentation allows us to implant those models in SCID CB17, athymic Nude, NOD-SCID, or CEIA NOG mice. If your model requires another strain of immunodeficient mice, we can make an amendment to our authorization within a few weeks. Our preferred strain is the SCID CB17 mice, as they allow an efficient but not too aggressive tumour uptake and their residual immune system is convenient to determine the antitumor efficacy of therapeutic antibodies.

Liquid tumours in Xenograft models

In vitro cultivated human cell lines are implanted into immunodeficient mice to create Cell line-Derived Xenograft (CDX) models, which are used to assess the effectiveness of potential
cancer treatments.
At Antineo, our liquid human cancer cell lines are available for subcutaneous or intravenous implantation. They may be monitored via bioluminescent imaging, routine blood collection,
and flow-cytometry detection of specific markers.
Antineo provides a wide range of liquid tumors in xenografts models, from Acute Lymphoblastoid Leukemia models to Burkitt’s Lymphoma or Diffuse Large B Cells Lymphoma models.

Acute Lymphoblastoid Leukemia, B cells
  • RS4;11 (View PDF)
  • 697 (On request)

Acute Lymphoblastoid Leukemia, B cells
  • CCRF-CEM (View PDF)
  • JM (View PDF)
  • Jurkat (On request)
  • Molt-4 (On request)
  • Reh (On request)

Acute Myeloid Leukemia

Chronic Lymphocitic Leuke mia, B cells

  • MEC1 (View PDF)
  • BV-173 (On request)

Burkitt's Lymphoma
  • Daudi (View PDF)
  • Ramos (View PDF)
  • Raji (View PDF)
  • EB2 (On request)
  • NaMalwa (On request)

Diffuse Large B Cells Lymphoma

Follicular Lymphoma
  • RL (View PDF)
  • DOHH2 (On request)

Mantle Cells Lymphoma

Myeloma
  • AMO1 (View PDF)
  • MM.1S (View PDF)
  • RPMI8226 (View PDF)
  • U266 (View PDF)
  • OPM-2 (On request)
  • LP1 (On request)
  • NCI-N929 (On request)

Cutaneous T lymphoma

  • Myla (View PDF)
  • HUT-78 (On request)

Solid tumours in Xenograft models

 

In mouse xenograft models, human tumor cells are inserted subcutaneously or orthotopically into immunocompromised mice to prevent the animal from developing a graft versus host reaction to the human tumor tissue. The response of human tumors to anti-cancer treatments may be examined using xenograft mice models.
The in vivo tumor models produced by Antineo come from a range of indications, including the breast, colon, lung, skin, ovary, etc. Our xenografts include orthotopic, subcutaneous,
and metastatic mouse models.
• Select a xenograft mouse model from our collection or get in touch with us to create a xenograft model for your particular in vivo efficacy study.
• Every in vivo tumor model has been established and verified.
• Many of our tumor models have been tested with standards of care
• Our scientific team can fully profile your agent in a range of tumor types or in conjunction with the right therapeutic agent, in addition to assisting you in choosing the best CDX model
for your compound.
• In Vivo Imaging: Orthotopic, metastatic, and bioluminescent subcutaneous cell line-derived xenograft models are available from Antineo.

Bladder cancer
  • ScaBER (On request)
  • 5637 (On request)
  • T24 (On request)
  • J82 (On request)
  • RT4 (On request)

Breast cancer
  • MCF7 (View PDF)
  • HCC1806 (View PDF)
  • BT474 (View PDF)
  • DU4475 (View PDF)
  • MDA-MB-157(On request)
  • MDA-MB-175 (On request)
  • MDA-MB-231 (View PDF)
  • MDA-MB-361(On request)
  • MDA-MB-436 (On request)
  • MDA-MB-453 (On request)
  • MDA-MB-468 (On request)
  • BT549 (On request)
  • JIMT-1 (On request)
  • SK-BR-3 (On request)
  • CAMA-1 (On request)
  • T47D (On request)
  • ZR-75-1 (On request)

Colorectal cancer
  • HCT 116 (View PDF)
  • HT-29 (View PDF)
  • Isreco-1 (View PDF)
  • SW620 (View PDF)
  • COLO 320 (On request)
  • Isreco-3 (On request)
  • SW403 (On request)

Esophagus cancer

Gastric cancer
  • SNU-5 (View PDF)
  • Hs746T (View PDF)
  • NCI-N87 (On request)

Glioblastoma
  • U251 (View PDF)
  • T98G (On request)
  • U-87 (View PDF)
  • ADF (On request)

Head and Neck cancer
  • FaDu (View PDF)
  • HN097 (View PDF)
  • CAL-27 (View PDF)
  • BICR 18 (View PDF)
  • BICR 22 (On request)
  • BICR 56 (On request)
  • DETROIT562 (On request)
  • H357 (On request)

Hepatic cancer

HepaRG (On request)
HepG2 (On request)

Lung cancer
  • A549 (View PDF)
  • NCI-H292 (View PDF)
  • NCI-H596 (On request)
  • NCI-H1703 (On request)
  • NCI-H1975 (View PDF)
  • HCC-78 (On request)
  • HCC95 (On request)
  • HCC827 (On request)
  • SK-MES-1 (On request)
  • MSTO-211H (Pleural Biphasic Mesothelioma) (On request)
  • ISTMes2 (Pleural Epithelioid Mesothelioma) (On request)

Melanoma
  • A2058 (View PDF)
  • MeWo (View PDF)
  • MEL Juso (View PDF)
  • Colo 829 (View PDF)
  • SK-MEL-2 (On request)
  • SK-MEL-5 (View PDF)
  • SK-MEL-24 (On request)
  • Malme-3 (On request)
  • A-375 (On request)
  • HMCB (On request)
  • Hs940T (On request)
  • IGR39 (On request)

Neuroblastoma cancer
  • SH-SY5Y (On request)

Ovarian cancer

Prostate cancer
  • DU145 (View PDF)
  • PC3 (View PDF)
  • LNCaP (On request)

Sarcoma

  • SK-LMS-1 (View PDF)
  • A-673 (On request)
  • MES-SA (On request)

Contact our Team to learn more

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