Our panel of in vitro continuous-monitoring assays is complementary to our end-point assays. The two apparatus used for such studies allow real-time analysis of a variety of cellular and immunological processes.

Those apparatus can also be used for some ex vivo experiments.

Preclinical Development :  In vitro continuous-monitoring studies


The xCELLigence® Real Time Cell Analysis instrument, developed by ACEA Biosciences, Inc. also allows continuous monitoring of adherent cells. The cells are seeded at the bottom of microtiter wells that are embedded with gold electrodes. The electrodes are used to measure impedance and its variations due to the presence of cells. The readout is the values of Cell Index, calculated as a function of the impedance.

This can be applied for analysis of:

  • Cytotoxicity
  • Immune cell killing (CTL and ADCC)
  • Phagocytosis
  • Migration & invasion
  • Other custom applications


The IncuCyte®, developed by Essen Biosciences, is a unique imagery platform, integrated in the controlled environment of an incubator. It allows the acquisition and subsequent quantification of cellular behaviour throughout the whole experiment, without disturbing the cells by removing them from the incubator.

In the field of Oncology, the IncuCyte® can analyse:

  • Cytotoxicity with specific reagents
  • Proliferation, with or without fluorescence
  • Apoptosis, by Caspase-3/7 or Annexin V labelling
  • Antibody internalisation
  • Migration & invasion (wound healing)
  • Immune cell, proliferation, clustering and killing (CTL and ADCC)
  • Phagocytosis
  • Other custom applications

Contact our Team to learn more