Syngeneic tumour models

Liquid tumours in Syngeneic models

Tumor tissues generated from the same genetic background as a particular mouse strain are referred to as syngeneic mouse models or allograft mouse tumor systems. Syngeneic models
are very useful for immuno-oncology research because they allow the investigation of tumor-immune system interactions in response to therapy. They make it possible to use the knowledge gained from in vitro screening and tests to the next level in vivo and get pharmacological or in vivo efficacy data.

Antineo provides a range of liquid tumors in syngeneic models, including models for leukemia, myeloma, and lymphoma.

Solid tumours in Syngeneic models

A syngeneic tumor model combines a complete, functioning immune system with an engrafted tumor derived from a genetically identical mouse strain. The development of cancer immunotherapies has been aided by the widespread use of murine syngeneic tumor models in cancer research during the past few decades. These tumor models are quite basic
cancer models, but recent reports have, however, indicated that the different inoculated cancer cell lines can lead to the formation of unique tumor microenvironments (TMEs).
Understanding the cellular and molecular makeup of the TME in the various models is crucial for drawing further conclusions from research based on syngeneic tumor models. Antineo
provides a wide variety of syngeneic mice models that have well-characterized responses to genetic assessment (e.g., RNA-seq), immunological profiling using flow cytometry, and
known immune checkpoint inhibitors (e.g., anti-PDL-1, anti-PD-1).
Our models benefit from a comprehensive understanding of their molecular profiles and are fully described cell models based on historical data. We have examined the immune
infiltration phenotype and responsiveness to standard of care (SOC) therapies in over 20 tumor cell lines.  Models from the collection include common cancer types, including liver, prostate, melanoma, colon, and pancreatic cancer.