Antineo : Pancreatic carcinoma tumour model – MIA PaCa-2
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MIA PaCa-2 cells
Human MIA PaCa-2 cells were isolated from the pancreas of a patient with pancreatic carcinoma.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing MIA PaCa-2 tumours can be treated by intra-peritoneal, intra-venous, intratumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1:(View PDF)
Tumour growth curve of the MIA PaCa-2 cells as xenograft Mean ± SEM (n=2; take rate 90%)