Antineo: Mantle Cells Lymphoma tumour model – NCEB
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NCBE cells
Human NCEB cells were isolated from the peripheral blood of a patient with non-hogkin’s mantle cells lymphoma.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing NCEB tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the NCEB cells as xenograft
Mean ± SEM (n=5; take rate 100%)
Antineo can also perform an intra-medullar implantation.
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Standard-Of-Care Drug Reponses
Rituximab, 30 mg/kg, bi-weekly → Response
Figure 2: View PDF
Effect of rituximab on NCEB tumour growth
Mean ± SEM (n=3 per group; take rate 100%)