Antineo : Colorectal Carcinoma tumour model – Isreco-1
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Isreco-1 cells
Human Isreco-1 cells were isolated from the colon of a patient with colorectal carcinoma.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing Isreco-1 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the Isreco-1 cells as xenograft Mean ± SEM (n=3; take rate 100%)
Antineo can also perform an intra-caecum implantation.