Antineo : Metastatic melanoma tumour model – SK-MEL-5
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SK-MEL-5 cells
Human SK-MEL-5 cells were isolated from the axillary nodes of a patient with metastatic melanoma.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing SK-MEL-5 tumours can be treated by intra-peritoneal, intra-venous, intratumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1:(View PDF)
Tumour growth curve of the SK-MEL-5 cells as xenograft Mean ± SEM (n=9; take rate 100%)