Antineo : Metastatic melanoma tumour model – MeWo
-
MeWo cells
Human MeWo cells were isolated from the lymph nodes of a patient with metastatic malignant melanoma.
-
Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing MeWO tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the MeWo cells as xenograft Mean ± SEM (n=10; take rate 90%)