Antineo: Melanoma Tumour model – Braf
▪ Braf cells
Mouse Braf cells were isolated from a V600EBRAF mutated melanoma.
▪ Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of
C57/Bl6 mice. The resulting tumours were monitored by measuring two diameters with calipers, and
extrapolating the volume to a sphere.
The mice bearing Braf tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or
subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (view PDF)
Tumour growth curve of the Braf cells as subcutaneous tumors Mean ± SEM (n=6; take rate 100%)