Antineo : Lung Carcinoma tumour model – A549
- A549 cells
Human A549 cells were isolated from the lung of a patient with lung carcinoma.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing A549 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the A549 cells as xenograft Mean ± SEM (n=3; take rate 100%)
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Standard-Of-Care Drug Reponses
trastuzumab 25 mg/kg bw → Response
Figure 2: (View PDF)
Effect of trastuzumab treatment on A549 tumour growth Mean ± SEM (n=6 per group; take rate 100%)