Lung Adenocarcinoma – NSCLC Tumour model – NCI-H1975

  • NCI-H1975 cells

Human NCI-H1975 cells were isolated from the lungs of a non-smoking female with non-small cell lung cancer.

  • Tumour growth in vivo

The cells were collected from a cell culture flask and 5×106 were injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.

The mice bearing NCI-H1975 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.

Figure 1:(View PDF)

Tumour growth curve of the NCI-H1975 cells as subcutaneous tumors (#2025-17-03 cells were injected with Matrigel). Mean ± SEM

 

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