Antineo : Lung Adenocarcinoma – NSCLC Tumour model – NCI-H1975
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NCI-H1975 cells
Human NCI-H1975 cells were isolated from the lungs of a nonsmoking patient with non-small cell lung cancer.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers,and extrapolating the volume to a sphere.
The mice bearing NCI-H1975 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1:(View PDF)
Tumour growth curve of the NCI-H1975 cells as subcutaneous tumors Mean ± SEM (n=6; take rate 100%)