Antineo: Breast adenocarcinoma syngeneic tumour model – E0771
▪ E0771 cells
Mouse E0771 cells were isolated from C57BL/6 mouse developing a spontaneous medullary breast adenocarcinoma.
▪ Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of C57BL/6 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing E0771 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the E0771 cells as subcutaneous tumours
Mean ± SEM (n=3; take rate 100%)
Antineo can also implant this model orthotopically.
▪ Drug Reponses
Anti-PD1 12.5 mg/kg → no response
Anti-PDL1 12.5 mg/kg → no response