B cells Lymphoma Tumour model – DEL

  • DEL cells

Human DEL cells were isolated from a pleural effusion of a patient with malignant histiocytosis.

  • Tumour growth in vivo

The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of NSG mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.

The mice bearing DEL tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.

Figure 1: (view PDF) Tumour growth curve of the DEL cells as subcutaneous tumors. Mean ± SEM (n=3

  • Luciferase model in vivo

Antineo has developed a DEL luciferase positive cell line for tumor growth follow-up with a luminescence imager (IVIS Lumina).  The cells were implanted subcutaneously in 3 mice (10 x 106 cells).

Figure 3: (view PDF) Bioluminescent signal of DEL cells for Mouse 2

Figure 4: (view PDF) Bioluminescent signal of DEL cells for Mouse 3 (primary tumor and metastasis)

Download PDF

Contact our Team to learn more

Contact