Antineo: Acute Myeloid Leukemia tumour model – Molm-13
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Molm-13 cells
Human molm-13 cells were isolated from a patient with Acute Myeloid Leukemia.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing Molm-13 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the Molm-13cells as xenograft
Mean ± SEM (n=3; take rate 100%)
Antineo can also perform an IV implantation, using hCD45 Flow Cytometry as follow-up of tumour
progression.