Antineo: Acute Myeloblastic Leukemia tumour model – Kasumi-1
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Kasumi-1 cells
Human Kasumi-1 cells were isolated from the peripheral blood from a child patient with Acute Myeloblastic Leukemia.
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Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of SCID-CB17 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing Kasumi-1 tumours can be treated by intra-peritoneal, intra-venous, intratumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1: (View PDF)
Tumour growth curve of the Kasumi-1 cells as xenograft
Mean ± SEM (n=4; take rate 100%)
Antineo can also perform an IV implantation, using hCD45 Flow Cytometry as follow-up of tumour
progression.