Syngeneic tumour model – E0771
- E0771 cells
Mouse E0771 cells were isolated from C57BL/6 mouse developing a spontaneous medullary breast adenocarcinoma.
Tumour growth in vivo
The cells were collected from a tissue culture flask and injected subcutaneously in the right flank of C57BL/6 mice. The resulting tumours were monitored by measuring two diameters with calipers, and extrapolating the volume to a sphere.
The mice bearing E0771 tumours can be treated by intra-peritoneal, intra-venous, intra-tumoral or subcutaneous injection of the compounds. Per os administration is also possible.
Figure 1:(View PDF)
Tumour growth curve of the E0771 cells as subcutaneous tumours Mean ± SEM (n=3)
Antineo can also implant this model orthotopically.
- Drug Reponses
Figure 2:(View PDF)
Tumour growth curve of the E0771 cells as subcutaneous tumours
Mean ± SEM (n=5)
The EO771 model does not respond to anti-PD1 or anti-PD1 at 12.5 mg/kg.