Preclinical Development in vitro continuous-monitoring studies


The xCELLigence® Real Time Cell Analysis instrument, developed by ACEA Biosciences, Inc. also allows continuous monitoring of adherent cells. The cells are seeded at the bottom of microtiter wells that are embedded with gold electrodes. The electrodes are used to measure impedance and its variations due to the presence of cells. The readout is the values of Cell Index, calculated as a function of the impedance.

This can be applied for analysis of:

  • Cytotoxicity
  • Immune cell killing (CTL and ADCC)
  • Phagocytosis
  • Migration & invasion
  • Other custom applications